A Green and Efficient Michael Addition of Indoles to α, β-unsaturated Electron-deficient Compounds and Synthesis of Bis-indolylmethanes Catalyzed by Gallium Dodecyl Sulfate [Ga(DS)3] in Water
α, β-unsaturated electron-deficient compounds and bis-indolylmethanes were successfully synthesized by gallium dodecyl sul-fate (Ga(DS)3) catalyzed Michael addition using indoles and α, β-unsaturated ketones(or aldehyde) as reactant, respectively. The samples were characterized by 1H NMR (400 MHz), HRMS, and Electrothermal Digital Melting-point. The results showed that the α, β-unsaturated electron-deficient compounds and bis-indolylmethanes could be effectively catalyzed by using Ga(DS)3 to give the corresponding adducts in good to excellent yields in water media.
This paper has not been published before. Upon its acceptance for publication in the Journal, I, as the only senior author, agree to transfer (to the extent transferable, if I am a Government employee) to the Journal of New Materials for Electrochemical Systems, or its assignee, all the rights under the existing Copyright laws, except for the following, which the author(s) specifically retain(s):
- the right to make further copies of all or part of the published article for my use in classroom teaching;
- the right to re-use all or part of the material in a compilation of my own words, or in a textbook of which I am the author;
- the right to make copies of the published work for internal distribution within the institution which employs me.
I agree to inform my co-authors, if any, of the terms of this arrangement.